A Study to Evaluate Safety and Anti-Tumor Activity of Eciskafusp Alfa (RO7284755) Alone or in Combination With Atezolizumab in Participants With Advanced and/or Metastatic Solid Tumors

Inclusion Criteria:

1. Locally advanced/unresectable or metastatic disease
2. No standard of care (SoC) (approved) treatments are available for the participant, or the participant cannot tolerate such treatments
3. Measurable disease, as defined by Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST v1.1)
4. Eastern Cooperative Oncology Group Performance Status 0 to 1
5. Life expectancy of >=12 weeks
6. Consent to provide an archival tumor tissue sample
7. Adequate cardiovascular, hematological, coagulative, hepatic and renal function

Exclusion Criteria:

1. Rapid disease progression or suspected hyperprogression or threat to vital organs or critical anatomical sites requiring urgent alternative medical intervention
2. Untreated central nervous system (CNS) metastases
3. Treated asymptomatic CNS metastases
4. Spinal cord compression not definitively treated with surgery and/or radiation or previously diagnosed and treated spinal cord compression without evidence that disease has been clinically stable for >= 2 weeks before Cycle1 Day 1 (C1D1)
5. Active or history of carcinomatous meningitis/leptomeningeal disease
6. Uncontrolled tumor-related pain or symptomatic hypercalcemia
7. Concurrent second malignancy
8. Evidence of significant, uncontrolled concomitant diseases that could affect compliance with the protocol or interpretation of results
9. Episode of significant cardiovascular/cerebrovascular acute disease within 28 days before study treatment administration
10. Active or uncontrolled infections
11. Known HIV infection
12. Hepatitis B virus (HBV) or hepatitis C virus infection
13. Adverse events related to any prior radiotherapy, chemotherapy, targeted therapy, CPI therapy or surgical procedure must have resolved to Grade <=1, except alopecia Grade 2 peripheral neuropathy, and hypothyroidism and/or hypopituitarism on a stable dosage of hormone replacement therapy
14. Participants with bilateral pleural effusion
15. Major surgery or significant traumatic injury < 28 days before study treatment administration or anticipation of the need for major surgery during study treatment
16. Known allergy or hypersensitivity to any component of the formulations of the IMPs to be administered, including but not limited to hypersensitivity to Chinese hamster ovary cell products or other recombinant or humanized antibodies
17. History of severe allergic anaphylactic reactions to chimeric, human or humanized antibodies, or fusion proteins
18. Previous treatment with Interleukin-2 (IL-2)/Interleukin-5 (IL-15)-like cytokines. IL-2/IL-15 use as an adjunct treatment component for adoptive cell therapy is permitted. In Part 3, patients who have received adoptive cell therapy such as tumor-infiltrating lymphocytes (TIL) are excluded.